Structure of PDB 5ofa Chain A Binding Site BS01

Receptor Information
>5ofa Chain A (length=531) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAE
RREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNG
LKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNAR
TREPVTDNVEKFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFN
LKLMDNGEPELDIISNPRDIQMAETKPERRSFRAYAAVLYIDPRMRIFIH
GHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKARE
AESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQR
ALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACG
GVVGVVDVPYLVLEPRHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQ
RGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRTL
PDTWVCSMNPDPEQDRCEASEQKQKVPLGTF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5ofa Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ofa Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Resolution2.57 Å
Binding residue
(original residue number in PDB)		C499 C502 C525 C536
Binding residue
(residue number reindexed from 1)		C491 C494 C506 C517
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.1.-
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5ofa, PDBe:5ofa, PDBj:5ofa
PDBsum5ofa
PubMed29440755
UniProtQ9Y6X9|MORC2_HUMAN ATPase MORC2 (Gene Name=MORC2)

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