Structure of PDB 5o8w Chain A Binding Site BS01

Receptor Information
>5o8w Chain A (length=449) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKEKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGK
GSFKYAWVLDKLKAERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKN
MITGTSQADCAILIIAGGVGEFEAGISKDGQTREHALLAFTLGVRQLIVA
VNKMDSVKWDESRFQEIVKETSNFIKKVGYNPKTVPFVPISGWNGDNMIE
ATTNAPWYKGWEKETKAGVVKGKTLLEAIDAIEQPSRPTDKPLRLPLQDV
YKIGGIGTVPVGRVETGVIKPGMVVTFAPAGVTTEVKSVEMHHEQLEQGV
PGDNVGFNVKNVSVKEIRRGNVCGDAKNDPPKGCASFNATVIVLNHPGQI
SAGYSPVLDCHTAHIACRFDELLEKNDRRSGKKLEDHPKFLKSGDAALVK
FVPSKPMCVEAFSEYPPLGRFAVRDMRQTVAVGVIKSVDKTAAAAAAAA
Ligand information
Ligand IDGLN
InChIInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChIKeyZDXPYRJPNDTMRX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)N)C(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)N)[C@@H](C(=O)O)N
ACDLabs 10.04O=C(N)CCC(N)C(=O)O
CACTVS 3.341N[CH](CCC(N)=O)C(O)=O
CACTVS 3.341N[C@@H](CCC(N)=O)C(O)=O
FormulaC5 H10 N2 O3
NameGLUTAMINE
ChEMBLCHEMBL930
DrugBankDB00130
ZINCZINC000001532526
PDB chain5o8w Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5o8w Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A.
Resolution1.67 Å
Binding residue
(original residue number in PDB)		E45 E48
Binding residue
(residue number reindexed from 1)		E44 E47
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D17 K20 S21 T72 H95
Catalytic site (residue number reindexed from 1) D16 K19 S20 T71 H94
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003779 actin binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0019901 protein kinase binding
GO:0043022 ribosome binding
GO:0051015 actin filament binding
GO:1904408 melatonin binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006409 tRNA export from nucleus
GO:0006412 translation
GO:0006414 translational elongation
GO:0006417 regulation of translation
GO:0006469 negative regulation of protein kinase activity
GO:0034198 cellular response to amino acid starvation
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0000329 fungal-type vacuole membrane
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005853 eukaryotic translation elongation factor 1 complex
GO:0005856 cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5o8w, PDBe:5o8w, PDBj:5o8w
PDBsum5o8w
PubMed28801462
UniProtP02994|EF1A_YEAST Elongation factor 1-alpha (Gene Name=TEF1)

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