Structure of PDB 5o76 Chain A Binding Site BS01

Receptor Information
>5o76 Chain A (length=385) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTIL
SRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRR
NLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTI
VPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQ
PWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTR
LGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDL
TGLCEPTPQDHIKVTQEQFELYCEMGSTFQLCKICAENDKDVKIEPCGHL
MCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPF
Ligand information
Receptor-Ligand Complex Structure
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PDB5o76 A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Resolution2.473 Å
Binding residue
(original residue number in PDB)		Y274 R294 S296 R299 Y307 Q316 T317 P319 F336 Y337
Binding residue
(residue number reindexed from 1)		Y225 R245 S247 R250 Y258 Q267 T268 P270 F287 Y288
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:5o76, PDBe:5o76, PDBj:5o76
PDBsum5o76
PubMed29053960
UniProtP22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL (Gene Name=CBL)

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