Structure of PDB 5o3v Chain A Binding Site BS01

Receptor Information

>5o3v Chain A (length=716) Species: 39387 (Gypsophila vaccaria)

SGFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQE
KLANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQ
NVFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLT
EWVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPLKEGED
HMTRSAVNQEARYHFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLL
YILDGCDDANKVYCLDLTKLPNGLESFSAPFMKLIDSFDASYTAIANDGS
VFTFQTNKDAPRKKLVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLI
LRYLSDVKHVLEIRDLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTS
ILTPGIVYQCDLKNDPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKI
PIFIAARKGISLDGSHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFC
LANIRGGGEYGEEWHKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAI
EGGANGGLLVAACINQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYG
CSDKEEEFKWLIKYSPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVP
LHSFKLLATMQHVLCTSLEDSPQKNPIIARIQRKAAHYGRATMTQIAEVA
DRYGFMAKALEAPWID

Ligand information

>5o3v Chain C (length=13) Species: 39387 (Gypsophila vaccaria)

VAWAFQANASAPV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5o3v Characterization of the Fast and Promiscuous Macrocyclase from Plant PCY1 Enables the Use of Simple Substrates.
• Resolution: 2.17 Å
• Binding residue (original residue number in PDB): R81 F95 A102 N104 F178 C259 Y481 S493 A494 S495 A562 N563 W603 R655 H695 Y696 T700 V707
• Binding residue (residue number reindexed from 1): R78 F92 A99 N101 F175 C256 Y473 S485 A486 S487 A554 N555 W595 R647 H687 Y688 T692 V699

Enzymatic activity

• Enzyme Commision number: 3.4.21.-
  3.4.21.26: prolyl oligopeptidase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding
• GO:0070012 oligopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5o3v, PDBe:5o3v, PDBj:5o3v
• PDBsum: 5o3v
• PubMed: 29377663
• UniProt: R4P353