Structure of PDB 5o2z Chain A Binding Site BS01

Receptor Information
>5o2z Chain A (length=104) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNEVVVQRLFQVKRRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGS
NSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPAL
PAGT
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5o2z Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5o2z Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		G186 D187 E209
Binding residue
(residue number reindexed from 1)		G33 D34 E56
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051015 actin filament binding

View graph for
Molecular Function
External links
PDB RCSB:5o2z, PDBe:5o2z, PDBj:5o2z
PDBsum5o2z
PubMed29069428
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN)

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