Structure of PDB 5nwa Chain A Binding Site BS01

Receptor Information
>5nwa Chain A (length=441) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVD
WLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAF
GTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGT
HKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTP
GRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADES
KWLCSEFKESMLTLGKESKTSSVPLYLIYPSVENVRTSLEGYPAGGSLPY
SIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLV
TSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFFPM
ATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5nwa Structural basis for DNA 3'-end processing by human tyrosyl-DNA phosphodiesterase 1.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		F259 H263 S400 G402 S403 P461 K469 H493 K495 S518 A520 R535
Binding residue
(residue number reindexed from 1)		F100 H104 S241 G243 S244 P299 K307 H331 K333 S356 A358 R373
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nwa, PDBe:5nwa, PDBj:5nwa
PDBsum5nwa
PubMed29295983
UniProtQ9NUW8|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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