Structure of PDB 5nw9 Chain A Binding Site BS01

Receptor Information
>5nw9 Chain A (length=431) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDW
LVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFG
THHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTH
KSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESK
WLCSEFKESMLTLGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTA
EKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANL
SKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQATFPVPYDLP
PELYGSKDRPWIWNIPYVKAPDTHGNMWVPS
Ligand information
Receptor-Ligand Complex Structure
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PDB5nw9 Structural basis for DNA 3'-end processing by human tyrosyl-DNA phosphodiesterase 1.
Resolution2.04 Å
Binding residue
(original residue number in PDB)		F259 H263 S400 G402 S403 P461 H493 K495 N516 S518 A520 R535
Binding residue
(residue number reindexed from 1)		F99 H103 S240 G242 S243 P294 H326 K328 N349 S351 A353 R368
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nw9, PDBe:5nw9, PDBj:5nw9
PDBsum5nw9
PubMed29295983
UniProtQ9NUW8|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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