Structure of PDB 5nw5 Chain A Binding Site BS01

Receptor Information

>5nw5 Chain A (length=1085) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ETRVNPRALEYWVSGEIHGLVDNESVSEFKEIIEGGLGILRQESEDYVAR
RFEVYATFNNIIPILTTKNVNEVDQKFNILIVNIESIIEICIPHLQIAQD
TLLSSSEKKNPFVIRLYVQIVRFFSAIMSNFKIVKWLTKRPDLVNKLKVI
YRWTTGALRNENSNKIIITAQVSFLRDEKFGTFFLSNEEIKPIISTFTEI
MEINSHNLIYEKLLLIRGFLSKYPKLMIETVTSWLPGEVLPRIIIGDEIY
SMKILITSIVVLLELLKKCLDFVDEHERIYQCIMLSPVCETIPEKFLSKL
PLNSYDSANLDKVTIGHLLTQQIKNYIVVKNDNKIAMDLWLSMTGLLYDS
GKRVYDLTSESNKVWFDLNNLCFINNHPKTRLMSIKVWRIITYCICTKIS
QKNQEGNKSLLSLLRTPFQMTLPYVNDPSAREGIIYHLLGVVYTAFTSNK
NLSTDMFELFWDHLITPIYEDYVFKYDSIHLQNVLFTVLHLLIGGKNADV
ALERKHIHPMSVIASEGVKLKDISSLPPQIIKREYDKIMKVVFQAVEVAI
SNVNLAHDLILTSLKHLPEDRKDQTHLESFSSLILKVTQNNKDTPIFRDF
FGAVTSSFVYTFLDLFLRKNDSSLVNFNIQISKVGISQGNMTLDLLKDVI
RKARNETSEFLIIEKFLELDDKKTEVYAQNWVGSTLLPPNISFREFQSLA
NIVNKVPNENSIENFLDLCLKLSFPVNLFTLLHVSMWSNNNFIYFIQSYV
SKNENKLNVDLITLLKTSLPGNPELFSGLLPFLRRNKFMDILEYCIHSNP
NLLNSIPDLNSDLLLKLLPRSRASYFAANIKLFKCSEQLTLVRWLLKGQQ
LEQLNQNFSEIENVLQNASDSELEKSEIIRELLHLAMANPIEPLFSGLLN
FCIKNNMADHLDEFCGNMTSEVLFKISPELLLKLLTYKEKPNGKLLAAVI
EKIENGDDDYILELLEKIIIQKEIQILEKLKEPLLVFFLNPVSSNMQKHK
KSTNMLRELVLLYLTKPLSRSAAKKFFSMLISILPPNPNYQTIDMVNLLI
DLIKSHNRKFKDKRTYNATLKTIGKWIQESGVVHQ

Ligand information

>5nw5 Chain C (length=30) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	5nw5 Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends.
Resolution	6.502 Å
Binding residue (original residue number in PDB)	K319 K451
Binding residue (residue number reindexed from 1)	K135 K267
Binding affinity	PDBbind-CN: Kd=21nM

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:5nw5, PDBe:5nw5, PDBj:5nw5
PDBsum	5nw5
PubMed	28604726
UniProt	P29539\|RIF1_YEAST Telomere length regulator protein RIF1 (Gene Name=RIF1)

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