Structure of PDB 5nv9 Chain A Binding Site BS01

Receptor Information
>5nv9 Chain A (length=480) Species: 529507 (Proteus mirabilis HI4320) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFGFINYAVLFGYLAAMLLVGVYFSKRQKTADDYFRGGGRVPGWAAGVSV
FATTLSSITFMSIPAKAYTSDWTFIIGQYLAIAILPLVFYFYIPFFRKLK
ITSAYEYLEARFDVRSRLFASLSFMLFHIGRVAIITYLTVLALRPFMGID
PVVLIVLISLLCIIYTWMGGIEGVIWTDVIQGLLLSGGAVLIFIMICFKV
DGGISEIFTTTAQADKFFPTTQWRWSWTDSTIPVLMIGFLFANIQQFTAS
QDVVQRYIVTDSIKETKRTLITNAKLVAIIPIFFFAIGSALFVYYQQNPS
LLPAGFNTGGILPLFIVTEMPIGIAGLIIAAIFAAAQSSISSSLNSISSC
FNSDIYTRLSKSSPSPEQKMKVAKLVIIVAGIFSSLAAIWLVLSDWDAFN
SLIGLMGGPMTGLFMLGIFVKRANAGSAVVGIIVSIIAVLAARYGSDLNF
FFYGVIGSMSVVIAGTITAPLFAPAKQLSL
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain5nv9 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5nv9 Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+site.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		A56 T57 L59 S60 A339 S342 S343
Binding residue
(residue number reindexed from 1)		A52 T53 L55 S56 A335 S338 S339
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nv9, PDBe:5nv9, PDBj:5nv9
PDBsum5nv9
PubMed29717135
UniProtB4EZY7|SIAT_PROMH Sodium/sialic acid symporter SiaT (Gene Name=siaT)

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