Structure of PDB 5nnu Chain A Binding Site BS01

Receptor Information
>5nnu Chain A (length=231) Species: 37296 (Human gammaherpesvirus 8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDRDLLLAPKWISFLSLSSFLKQKLLSLLRQIRELRLTTTVYPPQDKLMW
WSHCCDPEDIKVVILGQDPYHKGQATGLAFSVDPQCQVPPSLRSIFRELE
ASVPNFSTPSHGCLDSWARQGVLLLNTVLTVEKGSHELGWDWFTSFIISS
ISSKLEHCVFLLWGRKAIDRTPLINAQKHLVLTAQHPSPLASLGGRHSRW
PRFQGCNHFNLANDYLTRHRRETVDWGLLEQ
Ligand information
Receptor-Ligand Complex Structure
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PDB5nnu A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		Q90 D91 P113 S114 G191 R192 Q212 H213 S215 P216 L217 A218 G221 G222 S225
Binding residue
(residue number reindexed from 1)		Q67 D68 P90 S91 G164 R165 Q185 H186 S188 P189 L190 A191 G194 G195 S198
Enzymatic activity
Catalytic site (original residue number in PDB) D91 Y93 F103 H213
Catalytic site (residue number reindexed from 1) D68 Y70 F80 H186
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0097510 base-excision repair, AP site formation via deaminated base removal
Cellular Component
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nnu, PDBe:5nnu, PDBj:5nnu
PDBsum5nnu
PubMed29596604
UniProtF5HFA1|UNG_HHV8P Uracil-DNA glycosylase (Gene Name=ORF46)

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