Structure of PDB 5nhu Chain A Binding Site BS01

Receptor Information
>5nhu Chain A (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
Ligand information
>5nhu Chain J (length=29) Species: 7165 (Anopheles gambiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EEFDPSLLEEHADAPTARDPGRNPEFLRN
Receptor-Ligand Complex Structure
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PDB5nhu Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae.
Resolution1.45 Å
Binding residue
(original residue number in PDB)		Q344 E345 L346 H363 Y367 W370 L380 R388 Y391 I398 M400 E414 N415 L416 Q476 R498 I499 D519 A520 E522 G523 S525 W547 G548 E549 G550
Binding residue
(residue number reindexed from 1)		Q24 E25 L26 H43 Y47 W50 L60 R68 Y71 I78 M80 E94 N95 L96 Q149 R171 I172 D192 A193 E195 G196 S198 W220 G221 E222 G223
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:5nhu, PDBe:5nhu, PDBj:5nhu
PDBsum5nhu
PubMed28592490
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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