Structure of PDB 5ng6 Chain A Binding Site BS01 |
| >5ng6 Chain A (length=1268) Species: 401614 (Francisella tularensis subsp. novicida U112)
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NASIYQEFVNKYSLSKTLRFELIPQGKTLENIKARGLILDDEKRAKDYKK
AKQIIDKYHQFFIEEILSSVCISEDLLQNYSDVYFKLKKSDDDNLQKDFK
SAKDTIKKQISEYIKDSEKFKNLFNQNLIDAKKGQESDLILWLKQSKDNG
IELFKANSDITDIDEALEIIKSFKGWTTYFKGFHENRKNVYSSNDIPTSI
IYRIVDDNLPKFLENKAKYESLKDKAPEAINYEQIKKDLAEELTFDIDYK
TSEVNQRVFSLDEVFEIANFNNYLNQSGITKFNTIIGGKFVNGENTKRKG
INEYINLYSQQINDKTLKKYKMSVLFKQILSDTDKLEDDSDVVTTMQSFY
EQIAAFKTVEEKSIKETLSLLFDDLKAQKLDLSKIYFKNDKSLTDLSQQV
FDDYSVIGTAVLEYITQQIAPKNQELIAKKTEKAKYLSLETIKLALEEFN
KHRDIDKQCRFEEILANFAAIPMIFDEIAQNKDNLAQISIKYQNQGKKDL
LQASAEDDVKAIKDLLDQTNNLLHKLKIFHISQSEDKANILDKDEHFYLV
FEECYFELANIVPLYNKIRNYITQKPYSDEKFKLNFENSTLANGWDKNKE
PDNTAILFIKDDKYYLGVMNKKNNKIFDDKAIKENKGEGYKKIVYKLLPG
ANKMLPKVFFSAKSIKFYNPSEDILRIRNHSTHTKNGSPQKGYEKFEFNI
EDCRKFIDFYKQSISKHPEWKDFGFRFSDTQRYNSIDEFYREVENQGYKL
TFENISESYIDSVVNQGKLYLFQIYNKDFSAYSKGRPNLHTLYWKALFDE
RNLQDVVYKLNGEAELFYRKQSIPKKITHPAKEAIANKNKDNPKKESVFE
YDLIKDKRFTEDKFFFHCPITINFKSSGANKFNDEINLLLKEKANDVHIL
SIDRGERHLAYYTLVDGKGNIIKQDTFNIIGNDRMKTNYHDKLAAIERKD
WKKINNIKEMKEGYLSQVVHEIAKLVIEYNAIVVFEDLNFGFKRGRFKVE
KQVYQKLEKMLIEKLNYLVFKDNEFDKTGGVLRAYQLTAPFETFKKMGKQ
TGIIYYVPAGFTSKICPVTGFVNQLYPKYESVSKSQEFFSKFDKICYNLD
KGYFEFSFDYKNFAAKGKWTIASFGSRLINNWDTREVYPTKELEKLLKDY
SIEYGHGECIKAAICGESDKKFFAKLTSVLNTILQMRNSKTGTELDYLIS
PVADVNGNFFDSRQAPKNMPQDADANGAYHIGLKGLMLLGRIKNNQEGKK
LNLVIKNEEYFEFVQNRN |
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| PDB | 5ng6 Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a. |
| Resolution | 3.342 Å |
Binding residue
(original residue number in PDB) | S14 K15 T16 R18 Y47 K51 N185 K589 Y591 K595 N790 K791 S794 Y796 G799 R800 N802 L803 H804 R833 H843 I849 N851 K852 N853 K858 S861 V862 F863 Y865 I868 K869 D870 K871 R872 F879 H881 R948 M949 K956 S986 Q987 H990 K1034 K1041 |
Binding residue
(residue number reindexed from 1) | S15 K16 T17 R19 Y48 K52 N186 K575 Y577 K581 N776 K777 S780 Y782 G785 R786 N788 L789 H790 R819 H829 I835 N837 K838 N839 K844 S847 V848 F849 Y851 I854 K855 D856 K857 R858 F865 H867 R934 M935 K942 S966 Q967 H970 K1014 K1021 |
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| Enzyme Commision number |
3.1.21.1: deoxyribonuclease I.
4.6.1.22: Bacillus subtilis ribonuclease. |
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