Structure of PDB 5nfv Chain A Binding Site BS01 |
| >5nfv Chain A (length=1258) Species: 401614 (Francisella tularensis subsp. novicida U112)
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NASIYQEFVNKYSLSKTLRFELIPQGKTLENIKARGLILDDEKRAKDYKK
AKQIIDKYHQFFIEEILSSVCISEDLLQNYSDVYFKLKKSDDDNLQKDFK
SAKDTIKKQISEYIKDSEKFKNLFNQNLIDAKKSDLILWLKQSKDNGIEL
FKANSDITDIDEALEIIKSFKGWTTYFKGFHENRKNVYSSNDIPTSIIYR
IVDDNLPKFLENKAKYESLKDKAPEAINYEQIKKDLAEELTFDIDYKTSE
VNQRVFSLDEVFEIANFNNYLNQSGITKFNTIIGGKFVNGENTKRKGINE
YINLYSQQINDKTLKKYKMSVLFKQILSDTESKSFVIDKLEDDSDVVTTM
QSFYEQIAAFKTVEEKSIKETLSLLFDDLKAQKLDLSKIYFKNDKSLTDL
SQQVFDDYSVIGTAVLEYITQKTEKAKYLSLETIKLALEEFNKHRDIDKQ
CRFEEILANFAAIPMIFDEIAQNKDNLAQISIKYQNQGKKDLLQASAEDD
VKAIKDLLDQTNNLLHKLKIFHISQSEDKANILDKDEHFYLVFEECYFEL
ANIVPLYNKIRNYITQKPYSDEKFKLNFENSTLANGWDKNKEPDNTAILF
IKDDKYYLGVMNKKNNKIFDDKAIKENKGEGYKKIVYKLLPGANKMLPKV
FFSAKSIKFYNPSEDILRIRNHSTHTKNGSPQKGYEKFEFNIEDCRKFID
FYKQSISKHPEWKDFGFRFSDTQRYNSIDEFYREVENQGYKLTFENISES
YIDSVVNQGKLYLFQIYNKDFSAYSKGRPNLHTLYWKALFDERNLQDVVY
KLNGEAELFYRKQSIPKKITHPAKEAIANKNKDNPKKESVFEYDLIKDKR
FTEDKFFFHCPITINFKSSGANKFNDEINLLLKEKANDVHILSIDRGERH
LAYYTLVDGKGNIIKQDTFNIIGNDRMKTNYHDKLAAIEKDRDSARKDWK
KINNIKEMKEGYLSQVVHEIAKLVIEYNAIVVFQDLKVEKQVYQKLEKML
IEKLNYLVFKDNEFDKTGGVLRAYQLTAPFETFKKMGKQTGIIYYVPAGF
TSKICPVTGFVNQLYPKYESVSKSQEFFSKFDKICYNLDKGYFEFSFDYK
NFGDKAAKGKWTIASFGSRLINFRNDTREVYPTKELEKLLKDYSIEYGHG
ECIKAAICGESDKKFFAKLTSVLNTILQMANSKTDYLISPVADVNGNFFD
SRQAPKNMPQDADANGAYHIGLKGLMLLGRIKNNQEGKKLNLVIKNEEYF
EFVQNRNN |
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| PDB | 5nfv Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a. |
| Resolution | 2.501 Å |
Binding residue
(original residue number in PDB) | S14 K15 T16 R18 F19 E20 K51 N185 R186 R202 F289 N294 T295 Q309 F325 K326 L329 Y410 H538 K541 N580 R583 N790 K791 S794 Y796 S797 G799 R800 N802 L803 H804 E829 T842 I849 A850 N851 K852 N853 N856 K858 S861 V862 F863 Y865 L867 I868 K869 K871 R872 F879 H881 R948 K956 R968 E979 S986 Q987 H990 K1034 K1041 |
Binding residue
(residue number reindexed from 1) | S15 K16 T17 R19 F20 E21 K52 N183 R184 R200 F287 N292 T293 Q307 F323 K324 L327 Y408 H516 K519 N558 R561 N768 K769 S772 Y774 S775 G777 R778 N780 L781 H782 E807 T820 I827 A828 N829 K830 N831 N834 K836 S839 V840 F841 Y843 L845 I846 K847 K849 R850 F857 H859 R926 K934 R946 E957 S964 Q965 H968 K1003 K1010 |
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| Enzyme Commision number |
3.1.21.1: deoxyribonuclease I.
4.6.1.22: Bacillus subtilis ribonuclease. |
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