Structure of PDB 5nc2 Chain A Binding Site BS01
Receptor Information
>5nc2 Chain A (length=110) Species:
9606
(Homo sapiens) [
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SEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGR
KIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFA
SAMMHALEVL
Ligand information
>5nc2 Chain I (length=6) Species:
1639
(Listeria monocytogenes) [
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PPPPTE
Receptor-Ligand Complex Structure
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PDB
5nc2
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Resolution
1.58 Å
Binding residue
(original residue number in PDB)
Y16 W23 K69 N71 F77 Q79 R81
Binding residue
(residue number reindexed from 1)
Y15 W22 K68 N70 F76 Q78 R80
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5nc2
,
PDBe:5nc2
,
PDBj:5nc2
PDBsum
5nc2
PubMed
33184177
UniProt
Q8N8S7
|ENAH_HUMAN Protein enabled homolog (Gene Name=ENAH)
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