Structure of PDB 5n90 Chain A Binding Site BS01

Receptor Information
>5n90 Chain A (length=849) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRLGCNVSAPSGVLERVKELMEDYSRAPDAKFQQQFRHLLSVNFEEFVAE
TKERNADLDWVNPKLDERLQLELGQRQLEENAKKRLEARKKLPTMKYADD
IIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPR
RISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQ
QLQSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSA
TVREQDFCDYFNNCPMFRIEGVMFPVKMLYLEDVLSKTNYEFQKRMKHEA
MIEPYLRRIRNSYDSRVLDKLRLPESEGCEDIDFIADLVYYICENEPEGA
ILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLHSLMQSGEQQAV
FRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQSL
DEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDRMDDIPTPEILRSKL
ESIILSLKLLHIDDPYRFLQTLINAPNPEAIKMGVELLKRIEALDQTGTL
TPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYSPLG
KESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAERDFCYKNFLSS
MTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAIIGAG
LYPNMAHLRKSRRAIHTMATDDGRRVNFHPSSVNSGESGFDSAYFVYFQR
QKSTDLFLLDSTMVFPMALIIFGDGVEAGVTQNTPYLCVAKTYYFKCNRE
TADVVIQLRSNLEKLLLKKALYPAPIEENGYEKQLIKAIELLLSLDERL
Ligand information
Receptor-Ligand Complex Structure
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PDB5n90 Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.
Resolution3.069 Å
Binding residue
(original residue number in PDB)		R211 R212 Q237 R239 T255 G257 V258 Q261 Q262 Q264 S265 G431 Y432 H463 S464 L465 I491 S495 K511 T513 L524 E568 P635 I636 S664 R793 H809 P810 S833 T834
Binding residue
(residue number reindexed from 1)		R150 R151 Q176 R178 T194 G196 V197 Q200 Q201 Q203 S204 G357 Y358 H389 S390 L391 I417 S421 K437 T439 L450 E494 P561 I562 S590 R713 H729 P730 S753 T754
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0002151 G-quadruplex RNA binding
GO:0003676 nucleic acid binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0051880 G-quadruplex DNA binding
Biological Process
GO:0032508 DNA duplex unwinding
GO:0044806 G-quadruplex DNA unwinding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n90, PDBe:5n90, PDBj:5n90
PDBsum5n90
PubMed29429875
UniProtQ8SWT2

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