Structure of PDB 5n8s Chain A Binding Site BS01

Receptor Information
>5n8s Chain A (length=850) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRLGCNVSAPSGVLERVKELMEDYSRAPDAKFQQQFRHLLSVNFEEFVAE
TKERNADLDWVNPKLDERLQLELGQRQLEENAKKRLEARKKLPTMKYADD
IIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPR
RISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQ
QLQSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSA
TVREQDFCDYFNNCPMFRIEGVMFPVKMLYLEDVLSKTNYEFQKRRMKHE
AMIEPYLRRIRNSYDSRVLDKLRLPESEGCEDIDFIADLVYYICENEPEG
AILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLHSLMQSGEQQA
VFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQS
LDEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDRMDDIPTPEILRSK
LESIILSLKLLHIDDPYRFLQTLINAPNPEAIKMGVELLKRIEALDQTGT
LTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYSPL
GKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAERDFCYKNFLS
SMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAIIGA
GLYPNMAHLRKSRRAIHTMATDDGRRVNFHPSSVNSGESGFDSAYFVYFQ
RQKSTDLFLLDSTMVFPMALIIFGDGVEAGVTQNTPYLCVAKTYYFKCNR
ETADVVIQLRSNLEKLLLKKALYPAPIEENGYEKQLIKAIELLLSLDERL
Ligand information
Receptor-Ligand Complex Structure
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PDB5n8s Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.
Resolution2.88 Å
Binding residue
(original residue number in PDB)		R211 R212 Q237 R239 K244 T255 G257 Q261 Q262 Q264 G431 Y432 H463 S464 L465 T489 K511 T513 L524 K633 P635 F665 Q736 R793 H809 P810 S811 S833 T834 F837
Binding residue
(residue number reindexed from 1)		R150 R151 Q176 R178 K183 T194 G196 Q200 Q201 Q203 G358 Y359 H390 S391 L392 T416 K438 T440 L451 K560 P562 F592 Q663 R714 H730 P731 S732 S754 T755 F758
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0002151 G-quadruplex RNA binding
GO:0003676 nucleic acid binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0051880 G-quadruplex DNA binding
Biological Process
GO:0032508 DNA duplex unwinding
GO:0044806 G-quadruplex DNA unwinding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n8s, PDBe:5n8s, PDBj:5n8s
PDBsum5n8s
PubMed29429875
UniProtQ8SWT2

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