Structure of PDB 5n4d Chain A Binding Site BS01

Receptor Information
>5n4d Chain A (length=720) Species: 109633 (Galerina marginata) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WAPGNYPSTRRSDHVDTYQSASKGEVPVPDPYQWLEESTDEVDKWTTAQA
DLAQSYLDQNADIQKLAEKFRASRNYAKFSAPTLLDDGHWYWFYNRGLQS
QSVLYRSKEPALPDFSKGDDNVGDVFFDPNVLAADGSAGMVLCKFSPDGK
FFAYAVSHLGGDYSTIYVRSTSSPLSQASVAQGVDGRLSDEVKWFKFSTI
IWTKDSKGFLYQRYPARERHEGSDRNAMMCYHKVGTTQEEDIIVYQDNEH
PEWIYGADTSEDGKYLYLYQFKDTSKKNLLWVAELDEDGVKSGIHWRKVV
NEYAADYNIITNHGSLVYIKTNLNAPQYKVITIDLSKDEPEIRDFIPEEK
DAKLAQVNCANEEYFVAIYKRNVKDEIYLYSKAGVQLTRLAPDFVGAASI
ANRQKQTHFFLTLSGFNTPGTIARYDFTAPETQRFSILRTTKVNELDPDD
FESTQVWYESKDGTKIPMFIVRHKSTKFDGTAAAIQYGYGGFATSADPFF
SPIILTFLQTYGAIFAVPSIRGGGEFGEEWHKGGRRETKVNTFDDFIAAA
QFLVKNKYAAPGKVAINGASNGGLLVMGSIVRAPEGTFGAAVPEGGVADL
LKFHKFTGGQAWISEYGNPSIPEEFDYIYPLSPVHNVRTDKVMPATLITV
NIGAGRVVPMHSFKFIATLQHNVPQNPHPLLIKIDKSWLGHGMGKPTDKN
VKDAADKWGFIARALGLELK
Ligand information
>5n4d Chain C (length=18) Species: 109633 (Galerina marginata) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PWTAEHVDQTLASGNDIC
Receptor-Ligand Complex Structure
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PDB5n4d Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates.
Resolution1.62 Å
Binding residue
(original residue number in PDB)		K83 F84 S85 T88 L90 F98 S107 K149 F150 A408 R410 T419 G427 Y494 A503 D504 F506 E601 R663
Binding residue
(residue number reindexed from 1)		K78 F79 S80 T83 L85 F93 S102 K144 F145 A401 R403 T412 G420 Y487 A496 D497 F499 E594 R656
Enzymatic activity
Catalytic site (original residue number in PDB) Y496 S577 A661 H698
Catalytic site (residue number reindexed from 1) Y489 S570 A654 H691
Enzyme Commision number 3.4.21.26: prolyl oligopeptidase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0070012 oligopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n4d, PDBe:5n4d, PDBj:5n4d
PDBsum5n4d
PubMed29051530
UniProtH2E7Q8|POPB_GALM3 Dual function macrocyclase-peptidase POPB (Gene Name=POPB)

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