Structure of PDB 5n2g Chain A Binding Site BS01

Receptor Information
>5n2g Chain A (length=999) Species: 10249 (Vaccinia virus Copenhagen) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAMDPDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEI
YQSLSPPPFNARPLGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKK
RSIQNATMDEFLNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPR
NCFAKKIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGK
RLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLR
IAKQLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVH
LCIYERNQSSANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNA
FSCMGKVLNRGVREMTFIGDDTTDAKGKAAAFAKVLTTGNYVTVDEDIIC
KVIRKDIWENGFKVVLLCPTLPNDTYKLSFGKDDVDLAQMYKDYNLNIAL
DMARYCIHDACLCQYLWEYYGVETKTDAGASTYVLPQSMVFEYRASTVIK
GPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSL
YPNVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITVHCEP
RLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIY
DSMQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLN
GAELSNGMLRFANPLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTD
SVFTEIDSQDVDKSIEIAKELERLINNRVLFNNFKIEFEAVYKNLIMQSK
KKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEM
LSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSNYDNP
NMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDR
SFKLGSDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSKPTFYE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain5n2g Chain A Residue 1104 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5n2g The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		D166 E168 D462
Binding residue
(residue number reindexed from 1)		D170 E172 D459
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006310 DNA recombination
GO:0039693 viral DNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5n2g, PDBe:5n2g, PDBj:5n2g
PDBsum5n2g
PubMed29129932
UniProtP20509|DPOL_VACCC DNA polymerase (Gene Name=OPG071)

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