Structure of PDB 5mwy Chain A Binding Site BS01
Receptor Information
>5mwy Chain A (length=244) Species:
9606
(Homo sapiens) [
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YFSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWA
KVLPGFKNLPLEDQITLIQYSWMSLSSFALSWRSYKHTNSQFLYFAPDLV
FNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKD
GLKSQAAFEEMRTNYIKELRKMVTGQSWQRFYQLTKLLDSMHDLVSDLLE
FCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
Ligand information
>5mwy Chain B (length=10) Species:
9606
(Homo sapiens) [
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KSLLQQLLTE
Receptor-Ligand Complex Structure
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PDB
5mwy
Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
Resolution
1.75 Å
Binding residue
(original residue number in PDB)
V781 K785 L795 I799 A958 E962
Binding residue
(residue number reindexed from 1)
V47 K51 L61 I65 A218 E222
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5mwy
,
PDBe:5mwy
,
PDBj:5mwy
PDBsum
5mwy
PubMed
29474466
UniProt
P08235
|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)
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