Structure of PDB 5mpm Chain A Binding Site BS01

Receptor Information
>5mpm Chain A (length=992) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLL
ELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVA
NAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDI
VEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAV
NQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQ
QKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS
DKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFTITGSTYAPIGEVHKDDK
PVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTP
NKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIRE
WGSGSDTLRCLALATHDNPMRREEMNLEDSANFIKYETNLTFVGCVGMLD
PPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSK
AFTGREFDELNPSAQREACLNARCFARVEPSHKSKIVEFLQSFDEITAMT
GDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGR
AIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDG
LPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGA
AAWWFIAADGGPRVTFYQLSHFLQCKEDNPDFEGVDCAVFESPYPMTMAL
SVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVE
PLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLE
Ligand information
Ligand IDMGF
InChIInChI=1S/3FH.Mg/h3*1H;/q;;;+2/p-3
InChIKeyGJOMWUHGUQLOAC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Mg-](F)F
FormulaF3 Mg
NameTRIFLUOROMAGNESATE
ChEMBL
DrugBank
ZINC
PDB chain5mpm Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5mpm Structures of the heart specific SERCA2a Ca2+-ATPase.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		G182 D351 T353 T624 K683
Binding residue
(residue number reindexed from 1)		G182 D351 T353 T624 K683
Annotation score1
Enzymatic activity
Enzyme Commision number 7.2.2.10: P-type Ca(2+) transporter.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005388 P-type calcium transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0086039 P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
Biological Process
GO:0000045 autophagosome assembly
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0016240 autophagosome membrane docking
GO:0070588 calcium ion transmembrane transport
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0140056 organelle localization by membrane tethering
GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering
Cellular Component
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mpm, PDBe:5mpm, PDBj:5mpm
PDBsum5mpm
PubMed30777856
UniProtP11607|AT2A2_PIG Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (Gene Name=ATP2A2)

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