Structure of PDB 5mku Chain A Binding Site BS01

Receptor Information
>5mku Chain A (length=208) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMPVERILEAELAVDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQV
ILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDR
VLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYA
SLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPID
TFLMEMLE
Ligand information
Receptor-Ligand Complex Structure
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PDB5mku Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
Resolution1.78 Å
Binding residue
(original residue number in PDB)		V280 K284 L294 Q297 V298 R302 F450 E453
Binding residue
(residue number reindexed from 1)		V32 K36 L46 Q49 V50 R54 F202 E205
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mku, PDBe:5mku, PDBj:5mku
PDBsum5mku
PubMed28691794
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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