Structure of PDB 5mk4 Chain A Binding Site BS01

Receptor Information

>5mk4 Chain A (length=214) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DMPVERILEAELAVESSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELP
LDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVG
AIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALR
EKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIG
DTPIDTFLMEMLEA

Ligand information

>5mk4 Chain B (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KHKILHRLLQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5mk4 Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	V280 K284 L294 V298 L301 R302 F450 E453 E456
Binding residue (residue number reindexed from 1)	V37 K41 L51 V55 L58 R59 F207 E210 E213

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003707	nuclear steroid receptor activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:5mk4, PDBe:5mk4, PDBj:5mk4
PDBsum	5mk4
PubMed	28691794
UniProt	P19793\|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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