Structure of PDB 5mk3 Chain A Binding Site BS01

Receptor Information
>5mk3 Chain A (length=361) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLEL
LRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIF
SGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCA
AGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKS
FLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAA
VAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF
TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPA
VTGPDIFAKLV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5mk3 Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		M140 K141 Q148 L189 K192 R198 L202
Binding residue
(residue number reindexed from 1)		M140 K141 Q148 L189 K192 R198 L202
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Biological Process
GO:0071985 multivesicular body sorting pathway

View graph for
Biological Process
External links
PDB RCSB:5mk3, PDBe:5mk3, PDBj:5mk3
PDBsum5mk3
PubMed28602823
UniProtQ9H3S7|PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (Gene Name=PTPN23)

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