Structure of PDB 5mk1 Chain A Binding Site BS01

Receptor Information
>5mk1 Chain A (length=358) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQ
NAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGK
SVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGA
FAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLV
ARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAH
LHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTMD
VIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTG
PDIFAKLV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5mk1 Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E137 M140 K141 Q148 K192 R198 L202 L338
Binding residue
(residue number reindexed from 1)		E134 M137 K138 Q145 K189 R195 L199 L335
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Biological Process
GO:0071985 multivesicular body sorting pathway

View graph for
Biological Process
External links
PDB RCSB:5mk1, PDBe:5mk1, PDBj:5mk1
PDBsum5mk1
PubMed28602823
UniProtQ9H3S7|PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (Gene Name=PTPN23)

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