Structure of PDB 5mk0 Chain A Binding Site BS01

Receptor Information
>5mk0 Chain A (length=361) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLEL
LRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIF
SGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCA
AGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKS
FLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAA
VAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF
TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPA
VTGPDIFAKLV
Ligand information
>5mk0 Chain B (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DSYFKAAVSDLDKLLDDFEQ
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5mk0 Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Resolution1.765 Å
Binding residue
(original residue number in PDB)		F62 K141 T145 H146 C149 K192 R198 K199 L202 R205 A336 L338 D348
Binding residue
(residue number reindexed from 1)		F62 K141 T145 H146 C149 K192 R198 K199 L202 R205 A336 L338 D348
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Biological Process
GO:0071985 multivesicular body sorting pathway

View graph for
Biological Process
External links
PDB RCSB:5mk0, PDBe:5mk0, PDBj:5mk0
PDBsum5mk0
PubMed28602823
UniProtQ9H3S7|PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (Gene Name=PTPN23)

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