Structure of PDB 5mjy Chain A Binding Site BS01

Receptor Information
>5mjy Chain A (length=358) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQ
NAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGK
SVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGA
FAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLV
ARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAH
LHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTMD
VIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTG
PDIFAKLV
Ligand information
>5mjy Chain E (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ENYFQAEAYNLDKVLDEFEQ
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5mjy Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		P5 R6 K133 V135 D296 A297 F300 D303
Binding residue
(residue number reindexed from 1)		P2 R3 K130 V132 D293 A294 F297 D300
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Biological Process
GO:0071985 multivesicular body sorting pathway

View graph for
Biological Process
External links
PDB RCSB:5mjy, PDBe:5mjy, PDBj:5mjy
PDBsum5mjy
PubMed28602823
UniProtQ9H3S7|PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (Gene Name=PTPN23)

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