Structure of PDB 5mfx Chain A Binding Site BS01

Receptor Information
>5mfx Chain A (length=434) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKTRLRTVILAPTRVVAAEM
EEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVPNYNLY
IMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFPDSNSP
IMDTEVEVPERAWSSGFDWVTDYSGKTVWFVPSVRNGNEIAACLTKAGKR
VIQLSRKTFETEFQKTKHQEWDFVVTTDISEMGANFKADRVIDSRRCLKP
VILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYLYGGGCAETDE
DHAHWLEARMLLDNIYLQDGLIASLYRPEADKVAAIEGEFKLRTEQRKTF
VELMKRGDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSVPAEVWT
RHGEKRVLKPRWMDARVCSDHAALKSFKEFAAGK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5mfx How Zika virus NS3 helicase grips the first nucleotide of the leading RNA strand
Resolution1.598 Å
Binding residue
(original residue number in PDB)		T225 R226 T245 C262 A264 T265 D291 S365 V366 S387 R388 T409 D410 I411 L430 D540 R598
Binding residue
(residue number reindexed from 1)		T43 R44 T63 C80 A82 T83 D109 S183 V184 S205 R206 T227 D228 I229 L248 D358 R416
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5mfx, PDBe:5mfx, PDBj:5mfx
PDBsum5mfx
PubMed
UniProtA0A146CJH9

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