Structure of PDB 5m8o Chain A Binding Site BS01
Receptor Information
>5m8o Chain A (length=446) Species:
9606
(Homo sapiens) [
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QFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRP
HSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQ
RVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDG
NTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWH
RYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDS
TLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMV
QRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVR
SLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADIST
FPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPS
Ligand information
Ligand ID
0TR
InChI
InChI=1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9)
InChIKey
MDYOLVRUBBJPFM-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.352
OC1=CC=CC=CC1=O
OpenEye OEToolkits 1.6.1
C1=CC=C(C(=O)C=C1)O
Formula
C7 H6 O2
Name
2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE;
TROPOLONE
ChEMBL
CHEMBL121188
DrugBank
ZINC
ZINC000000392003
PDB chain
5m8o Chain A Residue 512 [
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Receptor-Ligand Complex Structure
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PDB
5m8o
Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
H192 H215 H377 H381 G389 Q390 T391 S394
Binding residue
(residue number reindexed from 1)
H168 H191 H353 H357 G365 Q366 T367 S370
Annotation score
1
Enzymatic activity
Enzyme Commision number
1.14.18.-
Gene Ontology
Molecular Function
GO:0016491
oxidoreductase activity
View graph for
Molecular Function
External links
PDB
RCSB:5m8o
,
PDBe:5m8o
,
PDBj:5m8o
PDBsum
5m8o
PubMed
28661582
UniProt
P17643
|TYRP1_HUMAN 5,6-dihydroxyindole-2-carboxylic acid oxidase (Gene Name=TYRP1)
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