Structure of PDB 5m5q Chain A Binding Site BS01

Receptor Information
>5m5q Chain A (length=219) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFK
YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPAQAA
AYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQ
EPFVAVVIDPTRKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVH
CKQYYALEVSYFKSSLDRK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5m5q Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5m5q Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H138 H140 D151
Binding residue
(residue number reindexed from 1)		H126 H128 D139
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.-.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:5m5q, PDBe:5m5q, PDBj:5m5q
PDBsum5m5q
PubMed27981705
UniProtQ92905|CSN5_HUMAN COP9 signalosome complex subunit 5 (Gene Name=COPS5)

[Back to BioLiP]