Structure of PDB 5m1s Chain A Binding Site BS01

Receptor Information
>5m1s Chain A (length=927) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSEPRFVHLRVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDFTNLCGL
VKFYGAGHGAGIKPIVGADFNVQCDLLGDELTHLTVLAANNTGYQNLTLL
ISKAYQRGYGAAGPIIDRDWLIELNEGLILLSGGRMGDVGRSLLRGNSAL
VDECVAFYEEHFPDRYFLELIRTGRPDEESYLHAAVELAEARGLPVVATN
DVRFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMRSEEEMCELF
ADIPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGL
EERLAFLFPDEEERLKRRPEYDERLETELQVINQMGFPGYFLIVMEFIQW
SKDNGVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMP
DFDVDFCMEKRDQVIEHVADMYGRDAVSQIITFGTMAAKAVIRDVGRVLG
HPYGFVDRISKLIPPDPGMTLAKAFEAEPQLPEIYEADEEVKALIDMARK
LEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQFDKSDVEYAG
LVKFDFLGLRTLTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDML
QRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRPGPLQSGMVDN
FIDRKHGREEISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGY
TLGGADMLRRAMGKKKPEEMAKQRSVFAEGAEKNGINAELAMKIFDLVEK
FAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTEKVVGL
VDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAII
EARNKGGYFRELFDLCARTDTKKLNRRVLEKLIMSGAFDRLGPHRAALMN
SLGDALKAADQHAKAEAIGQLDLFGVL
Ligand information
Receptor-Ligand Complex Structure
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PDB5m1s Self-correcting mismatches during high-fidelity DNA replication.
Resolution6.7 Å
Binding residue
(original residue number in PDB)		P452 Y453 R877
Binding residue
(residue number reindexed from 1)		P452 Y453 R877
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5m1s, PDBe:5m1s, PDBj:5m1s
PDBsum5m1s
PubMed28067916
UniProtP10443|DPO3A_ECOLI DNA polymerase III subunit alpha (Gene Name=dnaE)

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