Structure of PDB 5lwy Chain A Binding Site BS01

Receptor Information
>5lwy Chain A (length=285) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFEGRWRVIPHDVLPDWLKDNDFLLHGHRPPMPSFRACFKSIFRIHTETG
NIWTHLLGCVFFLCLGIFYMFRPNISFVAPLQEKVVFGLFFLGAILCLSF
SWLFHTVYCHSEGVSRLFSKLDYSGIALLIMGSFVPWLYYSFYCNPQPCF
IYLIVICVLGIAAIIVSQWDMFATPQYRGVRAGVFLGLGLSGIIPTLHYV
ISEGFLKAATIGQIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHS
HQLFHIFVVAGAFVHFHGVSNLQEFRFMIGGGCSE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5lwy Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5lwy Structural insights into adiponectin receptors suggest ceramidase activity.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H202 H348 H352
Binding residue
(residue number reindexed from 1)		H105 H251 H255
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:5lwy, PDBe:5lwy, PDBj:5lwy
PDBsum5lwy
PubMed28329765
UniProtQ86V24|PAQR2_HUMAN Adiponectin receptor protein 2 (Gene Name=ADIPOR2)

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