Structure of PDB 5lu8 Chain A Binding Site BS01

Receptor Information
>5lu8 Chain A (length=263) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIA
YSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVK
GIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYK
HKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKR
STYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTQTSHVMQYGNKTI
STMKVMQFQGMKR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5lu8 Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		G26 R44 H45 X147 H148 C189 S216 Y217 A218 Y228 D231 W232
Binding residue
(residue number reindexed from 1)		G1 R19 H20 X122 H123 C164 S191 Y192 A193 Y203 D206 W207
Enzymatic activity
Enzyme Commision number 3.4.22.34: legumain.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5lu8, PDBe:5lu8, PDBj:5lu8
PDBsum5lu8
PubMed28345579
UniProtQ99538|LGMN_HUMAN Legumain (Gene Name=LGMN)

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