Structure of PDB 5lu7 Chain A Binding Site BS01

Receptor Information

>5lu7 Chain A (length=193) Species: 272560 (Burkholderia pseudomallei K96243)

NRELTYITNSIAEAQRVMAAMLADERLLATVRKVADACIASIAQGGKVLL
AGNGGSAAAAQHIAGEFVSRFAFDRPGLPAVALTTDTSILTAIGNDYGYE
KLFSRQVQALGNEGDVLIGYSTSGKSPNILAAFREAKAKGMTCVGFTGNR
GGEMRELCDLLLEVPSADTPKIQEGHLVLGHIVCGLVEHSIFG

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5lu7 Chain A Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5lu7 A half-site multimeric enzyme achieves its cooperativity without conformational changes.
• Resolution: 1.92 Å
• Binding residue (original residue number in PDB): H64 E68 H183
• Binding residue (residue number reindexed from 1): H62 E66 H181
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.3.1.28: D-sedoheptulose-7-phosphate isomerase.

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0008968 D-sedoheptulose 7-phosphate isomerase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding
• GO:0097367 carbohydrate derivative binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0045227 capsule polysaccharide biosynthetic process
• GO:1901135 carbohydrate derivative metabolic process
• GO:2001061 D-glycero-D-manno-heptose 7-phosphate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5lu7, PDBe:5lu7, PDBj:5lu7
• PDBsum: 5lu7
• PubMed: 29184087
• UniProt: Q93UJ2|GMHA_BURPS Phosphoheptose isomerase (Gene Name=gmhA)