Structure of PDB 5ltk Chain A Binding Site BS01

Receptor Information
>5ltk Chain A (length=700) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTAKQAEAVEDSDINPWTGQRHSERYFKILKARRKLPVNKQRQEFLDLYH
NNQILVFVGETGSGKTTQIPQYVLYDELPHQTGKLIACTQPRRVAAMSVA
QRVADELDVKLGEEVGYSIRFENKTSSKTLLKYMTDGQLLREAMHDRDMS
RYSCIILDEAHERTLATDILMALLKQLSERRKDLKIIVMSATLDAQKFQS
YFFNAPLLAVPGRTHPVEIFYTPEAERDYVEAAIRTVLQIHACEPEGDIL
LFLTGEEEIEDACRRISLEVDEMIRESDAGPMSVYPLYGTLPPHQQQRIF
EKAPQPFRPGGRPGRKCIVATNIAETSLTIDGIVYVVDPGFSKQKIYNPR
TRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFKKELIEQTYP
EILRSNLSNTVLELKKLGVEDLVHFDLMDPPAPETMMRALEELNYLACLD
DDGELTPLGNLASEFPLDPALAVMLISSPEFYCSNEILSITSLLSVPQIW
VRPANARKRADEMKAQFAHPDGDHLTLLNAYHAYKGAEARGEDMKKWCHE
HFLSYRHLSSADNVRAQLKKIMETHGIELVSTPFHDKNYYTNIRRALLAG
FFMQVAMRESSNSKVYKTVKDEQLVLIHPSTTVTTPYEWVVYNEFVLTTK
QYVRTVTNIRPEWLLEIAPVYYDLSTFQKGEIKNALTRVAEKIRRQQAMK
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain5ltk Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ltk Structural insights into the mechanism of the DEAH-box RNA helicase Prp43.
Resolution3.241 Å
Binding residue
(original residue number in PDB)		G122 G124 K125 T126 T127 R162 T389 R435
Binding residue
(residue number reindexed from 1)		G62 G64 K65 T66 T67 R102 T329 R375
Annotation score5
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005681 spliceosomal complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5ltk, PDBe:5ltk, PDBj:5ltk
PDBsum5ltk
PubMed28092261
UniProtG0RY84

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