Structure of PDB 5lta Chain A Binding Site BS01

Receptor Information

>5lta Chain A (length=698) Species: 759272 (Thermochaetoides thermophila DSM 1495)

TTAKQAEAVEDSDINPWTGQRHSERYFKILKARRKLPVNKQRQEFLDLYH
NNQILVFVGETGSGKTTQIPQYVLYDELPHQTGKLIACTQPRRVAAMSVA
QRVADELDVKLGEEVGYSIRFENKTSSKTLLKYMTDGQLLREAMHDRDMS
RYSCIILDEAHERTLATDILMALLKQLSERRKDLKIIVMSATLDAQKFQS
YFFNAPLLAVPGRTHPVEIFYTPEAERDYVEAAIRTVLQIHACEPEGDIL
LFLTGEEEIEDACRRISLEVDEMIRESDAGPMSVYPLYGTLPPHQQQRIF
EKAPQPFRPGGRPGRKCIVATNIAETSLTIDGIVYVVDPGFSKQKIYNPR
TRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFKKELIEQTYP
EILRSNLSNTVLELKKLGVEDLVHFDLMDPPAPETMMRALEELNYLACLD
DDGELTPLGNLASEFPLDPALAVMLISSPEFYCSNEILSITSLLSVPQIW
VRPANARKRADEMKAQFAHPDGDHLTLLNAYHAYKGAEARGEDMKKWCHE
HFLSYRHLSSADNVRAQLKKIMETHGIELVSTPFHDKNYYTNIRRALLAG
FFMQVAMRESSNSKVYKTVKDEQLVLIHPSTTVTTPYEWVVYNEFVLTTK
QYVRTVTNIRPEWLLEIAPVYYDLSTFQKGEIKNALTRVAEKIRRQQA

Ligand information

>5lta Chain E (length=8)

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........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5lta Structural insights into the mechanism of the DEAH-box RNA helicase Prp43.
• Resolution: 2.621 Å
• Binding residue (original residue number in PDB): R152 R153 I179 R180 T195 G197 Q198 R201 T314 G315 E316 E317 Y348 G349 T381 N382 I383 K403 L416 P526 S555 V556 P557 R562 Q627 H688 P689 S690 R714
• Binding residue (residue number reindexed from 1): R92 R93 I119 R120 T135 G137 Q138 R141 T254 G255 E256 E257 Y288 G289 T321 N322 I323 K343 L356 P466 S495 V496 P497 R502 Q567 H628 P629 S630 R654

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003724 RNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Cellular Component

• GO:0005681 spliceosomal complex
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5lta, PDBe:5lta, PDBj:5lta
• PDBsum: 5lta
• PubMed: 28092261
• UniProt: G0RY84