Structure of PDB 5lsw Chain A Binding Site BS01

Receptor Information
>5lsw Chain A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGT
IAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLA
AHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTE
IIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMI
LGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTF
AQVLKDDTTTKRWLAQLVKNLQE
Ligand information
>5lsw Chain B (length=21) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EGGIDSGMMLQLEKNLVDIVD
Receptor-Ligand Complex Structure
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PDB5lsw A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		H85 N88 Q98 R130 Y134 L137 G141 K148 L177 F184 R227 H231
Binding residue
(residue number reindexed from 1)		H73 N76 Q86 R118 Y122 L125 G129 K136 L165 F172 R215 H219
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006402 mRNA catabolic process
Cellular Component
GO:0030014 CCR4-NOT complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5lsw, PDBe:5lsw, PDBj:5lsw
PDBsum5lsw
PubMed28165457
UniProtQ92600|CNOT9_HUMAN CCR4-NOT transcription complex subunit 9 (Gene Name=CNOT9)

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