Structure of PDB 5lst Chain A Binding Site BS01

Receptor Information
>5lst Chain A (length=617) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVLPLYSLGPSGQLAETPAEVFQALEQLGHQAFRPGQERAVMRILSGIST
LLVLPTGAGKSLCYQLPALLYSRRSPCLTLVVSPLLSLMDDQVSGLPPCL
KAACIHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPP
VAFACIDEAHCLSQWSHNFRPCYLRVCKVLRERMGVHCFLGLTATATRRT
ASDVAQHLAVAEEPDAPVPTNLHLSVSMDRDTDQALLTLLQGKRFQNLDS
IIIYCNRREDTERIAALLRTCLHARAPKTTAEAYHAGMCSRERRRVQRAF
MQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQ
PAHCHLFLQPQGEDLRELRRHVHADSTDFLAVKRLVQRVFPACTCTCEQL
SHQAAPGPRRVCMGHERALPIQLTVQALDMPEEAIETLLCYLELHPHHWL
ELLATTYTHCRLNCPGGPAQLQALAHRCPPLAVCLAQQLSVEFDMVKLVD
SMGWELASVRRALCQLQWDHEPRTGVRRGTGVLVEFSELAFHLRSPGDLT
AEEKDQICDFLYGRVQARERQALARLRRTFQAFHSVAFPSCGPCLEQQDE
ERSTRLKDLLGRYFEEE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5lst Chain A Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5lst The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		C853 C855 C897 H900
Binding residue
(residue number reindexed from 1)		C393 C395 C412 H415
Annotation score1
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:5lst, PDBe:5lst, PDBj:5lst
PDBsum5lst
PubMed28653661
UniProtO94761|RECQ4_HUMAN ATP-dependent DNA helicase Q4 (Gene Name=RECQL4)

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