Structure of PDB 5lpp Chain A Binding Site BS01

Receptor Information
>5lpp Chain A (length=340) Species: 264203 (Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATADIILGNTY
HLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQSEEGVTFMLSPERSI
EIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAKRSRDAFDSRKE
QAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEMF
RVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNG
QAFTWDGPINIRNARFSEDLKPLDCHCAVCQKWSRAYIHHLIRAGEILGA
MLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRARYFA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5lpp Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5lpp Carbohydrate-based Inhibitors targeting the Ribose-34 pocket of Z.mobilis TGT and changing the oligomeric state of the homodimer
Resolution1.99 Å
Binding residue
(original residue number in PDB)		C318 C320 C323 H349
Binding residue
(residue number reindexed from 1)		C275 C277 C280 H306
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D102 D280 C318 C320 C323 H349
Catalytic site (residue number reindexed from 1) D80 D239 C275 C277 C280 H306
Enzyme Commision number 2.4.2.29: tRNA-guanosine(34) preQ1 transglycosylase.
Gene Ontology
Molecular Function
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0002099 tRNA wobble guanine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0008616 queuosine biosynthetic process
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lpp, PDBe:5lpp, PDBj:5lpp
PDBsum5lpp
PubMed
UniProtP28720|TGT_ZYMMO Queuine tRNA-ribosyltransferase (Gene Name=tgt)

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