Structure of PDB 5lpe Chain A Binding Site BS01

Receptor Information

>5lpe Chain A (length=204) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PCARGSQPWQVSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDQG
EQLRRTTRSVVHPKYRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPG
DQCQVAGWGTTANKGLTCSSITILSPKECEVFYPGVVTNNMICAGLDRGQ
DPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKV
IRSN

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5lpe Chain A Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5lpe Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10.
Resolution	2.65 Å
Binding residue (original residue number in PDB)	H57 D99 D102
Binding residue (residue number reindexed from 1)	H36 D68 D71
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D102 Q192 S193 D194 S195 G196
Catalytic site (residue number reindexed from 1)	H36 D71 Q154 S155 D156 S157 G158
Enzyme Commision number	3.4.21.-

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0005576	extracellular region
GO:0030141	secretory granule

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Cellular Component

External links

PDB	RCSB:5lpe, PDBe:5lpe, PDBj:5lpe
PDBsum	5lpe
PubMed	27611765
UniProt	O43240\|KLK10_HUMAN Kallikrein-10 (Gene Name=KLK10)

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