Structure of PDB 5lop Chain A Binding Site BS01

Receptor Information
>5lop Chain A (length=259) Species: 284590 (Kluyveromyces lactis NRRL Y-1140) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLPLLRPFETVSLENAVEDLVVRFILNVPPEDLSTVERVLFHFEEASWFY
TDFVKLMNPYLPNLSIKSFSKIVIDICPLIWNWDITPENALVKFSNYKKT
IPVRGAAIFNDSLSKILLLRGINSKHWSFPRGKIGKDEDDVACCIREVKE
ETGFDLTGFIDADQYVERNMNGKNFKIFLVKGVPEDFEFKPEHKNEIQAI
EWKDFKKLSKAITKNEGFLVNSMIRPLSLYVKNEKRAKDENKLKLYAEEH
LKSILGLNK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5lop Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5lop Structure of the active form of Dcp1-Dcp2 decapping enzyme bound to m(7)GDP and its Edc3 activator.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		R132 E152
Binding residue
(residue number reindexed from 1)		R131 E151
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5lop, PDBe:5lop, PDBj:5lop
PDBsum5lop
PubMed27694841
UniProtQ6CIU1

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