Structure of PDB 5lm9 Chain A Binding Site BS01

Receptor Information

>5lm9 Chain A (length=319) Species: 83333 (Escherichia coli K-12)

FDRITTQTAKQVIVQKVREAERAMVVDQFREHEGEIITGVVKKVNRDNIS
LDLGNNAEAVILREDMLPRENFRPGDRVRGVLYSVRPEARGAQLFVTRSK
PEMLIELFRIEVPEIGEEVIEIKAAARDPGSRAKIAVKTNDKRIDPVGAC
VGMRGARVQAVSTELGGERIDIVLWDDNPAQFVINAMAPADVASIVVDED
KHTMDIAVEAGNLAQAIGRNGQNVRLASQLSGWELNVMTVDDLQAKHQAE
AHAAIDTFTKYLDIDEDFATVLVEEGFSTLEELAYVPMKELLEIEGLDEP
TVEALRERAKNALATIAQA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5lm9 Chain A Residue 506

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5lm9 Structural basis for lambda N-dependent processive transcription antitermination.
• Resolution: 2.143 Å
• Binding residue (original residue number in PDB): V297 H348 E351
• Binding residue (residue number reindexed from 1): V196 H247 E250
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003676 nucleic acid binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0003723 RNA binding

Biological Process

• GO:0006353 DNA-templated transcription termination
• GO:0031554 regulation of termination of DNA-templated transcription
• GO:0031564 transcription antitermination

External links

• PDB: RCSB:5lm9, PDBe:5lm9, PDBj:5lm9
• PDBsum: 5lm9
• PubMed: 28452979
• UniProt: P0AFF6|NUSA_ECOLI Transcription termination/antitermination protein NusA (Gene Name=nusA)