Structure of PDB 5lk1 Chain A Binding Site BS01

Receptor Information

>5lk1 Chain A (length=410)

TPVWNDNAHGVGSVPMHTDLELDFSLTSSSKYTYRRKLTNPLEEAQSIDL
HIEIEEQTIGVDVHALGHWFDGRLNLKTSFHCYGACTKYEYPWHTAKCHY
ERDYQYETSHGCNPSDCPGVGTGCTACGLYLDQLKPVGSAYKIITIRYSR
RVCVQFGEENLCKIIDMNDCFVSRHVKVCIIGTVSKFSQGDTLLFFGPLE
GGGLIFKHWCTSTCQFGDPGDIMSPRDKGFLCPEFPGSFRKKCNFATTPI
CEYDGNMVSGYKKVMATIDSFQSFNTSTMHFTDERIEWKDPDGMLRDHIN
ILVTKDIDFDNLGENPCKIGLQTSSIEGAWGSGVGFTLTCLVSLTECPTF
LTSIKACDKAICYGAESVTLTRGQNTVKVSGKGGHSGSTFRCCHGEDCSQ
IGLHAAAPHL

Ligand information

• Ligand ID: FUL
• InChI: InChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6-/m0/s1
• InChIKey: SHZGCJCMOBCMKK-KGJVWPDLSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C[C@H]1[C@H]([C@H]([C@@H]([C@H](O1)O)O)O)O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)C
  CACTVS 3.341: C[C@@H]1O[C@H](O)[C@@H](O)[C@H](O)[C@@H]1O
  OpenEye OEToolkits 1.5.0: CC1C(C(C(C(O1)O)O)O)O
  CACTVS 3.341: C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
• Formula: C6 H12 O5
• Name: beta-L-fucopyranose;
  beta-L-fucose;
  6-deoxy-beta-L-galactopyranose;
  L-fucose;
  fucose;
  6-DEOXY-BETA-L-GALACTOSE
• ChEMBL: CHEMBL1230861
• DrugBank: DB03283
• ZINC: ZINC000001532813
• PDB chain: 5lk1 Chain B Residue 3

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5lk1 Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): F201 L204 G208 L209
• Binding residue (residue number reindexed from 1): F196 L199 G203 L204
• Annotation score: 4

Gene Ontology

Biological Process

• GO:0019049 virus-mediated perturbation of host defense response

Cellular Component

• GO:0044423 virion component

External links

• PDB: RCSB:5lk1, PDBe:5lk1, PDBj:5lk1
• PDBsum: 5lk1
• PubMed: 27783711
• UniProt: P08668|GP_HANTV Envelopment polyprotein (Gene Name=GP)