Structure of PDB 5lih Chain A Binding Site BS01

Receptor Information
>5lih Chain A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVWVQTEKH
VFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEH
ARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGL
RPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFD
IQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTG
FADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ
LTPDDDDIVRKIDQSEFEGFEYINPL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5lih aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		S264 M341 Q345 D382 M399 F413 C414 G415 T416 P417 E445 G449
Binding residue
(residue number reindexed from 1)		S17 M87 Q91 D128 M145 F159 C160 G161 T162 P163 E191 G195
Enzymatic activity
Catalytic site (original residue number in PDB) D378 K380 N383 D396 T416
Catalytic site (residue number reindexed from 1) D124 K126 N129 D142 T162
Enzyme Commision number 2.7.11.13: protein kinase C.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007163 establishment or maintenance of cell polarity

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Molecular Function
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Biological Process
External links
PDB RCSB:5lih, PDBe:5lih, PDBj:5lih
PDBsum5lih
PubMed27554858
UniProtP41743|KPCI_HUMAN Protein kinase C iota type (Gene Name=PRKCI)

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