Structure of PDB 5lhz Chain A Binding Site BS01

Receptor Information
>5lhz Chain A (length=78) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQT
TRYGENEKLPDYIKQKLQCLSSILLMFS
Ligand information
>5lhz Chain D (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
QDRQLRLLQAQIQRLLEAQSLM
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5lhz A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		Q901 V907 V919 Q920 A921 V923 E942 K943 L944 L960
Binding residue
(residue number reindexed from 1)		Q16 V22 V34 Q35 A36 V38 E57 K58 L59 L75
Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
External links
PDB RCSB:5lhz, PDBe:5lhz, PDBj:5lhz
PDBsum5lhz
PubMed28202467
UniProtO00444|PLK4_HUMAN Serine/threonine-protein kinase PLK4 (Gene Name=PLK4)

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