Structure of PDB 5lhp Chain A Binding Site BS01

Receptor Information
>5lhp Chain A (length=247) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVGGEFTEVENQPWFAAIYQKNKGGSPPSFKCGGSLISPCWVASAAHCFI
QLPKKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIA
LLKIRTSTGQCAQPSRSIQTIALPPRFTDAPFGSDCEITGFGKESESDYL
YPKNLKMSVVKLVSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSG
GPLICNIEGRPTLSGIVSWGRGCAEKNKPGVYTRVSHFLDWIQSHIG
Ligand information
Ligand IDPBZ
InChIInChI=1S/C7H9N3/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H3,9,10)/p+1
InChIKeyWPANETAWYGDRLL-UHFFFAOYSA-O
SMILES
SoftwareSMILES
ACDLabs 10.04N/C(c1ccc(N)cc1)=[NH2+]
OpenEye OEToolkits 1.5.0c1cc(ccc1C(=[NH2+])N)N
CACTVS 3.341NC(=[NH2+])c1ccc(N)cc1
FormulaC7 H10 N3
NameP-AMINO BENZAMIDINE
ChEMBL
DrugBank
ZINC
PDB chain5lhp Chain A Residue 311 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5lhp Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Resolution2.63 Å
Binding residue
(original residue number in PDB)		D189 S190 V213 W215 G218
Binding residue
(residue number reindexed from 1)		D193 S194 V217 W219 G222
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H47 D98 K196 G197 D198 S199 G200
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5lhp, PDBe:5lhp, PDBj:5lhp
PDBsum5lhp
PubMed28611361
UniProtP06869|UROK_MOUSE Urokinase-type plasminogen activator (Gene Name=Plau)

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