Structure of PDB 5lg6 Chain A Binding Site BS01

Receptor Information
>5lg6 Chain A (length=889) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ITLDQSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRFI
CQEPTDVIIIHSKKLNYTMVVLRGVGDSQVPEIDRTELVELTEYLVVHLK
GSLQPGHMYEMESEFQGELADDLAGFYRSEYMEGNVKKVLATTQMQSTDA
RKSFPCFDEPAMKATFNITLIHPNNLTALSNMPPKGSSTPLAEDPNWSVT
EFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWARPNAIAEGHGMYA
LNVTGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRENAL
LFDPQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYV
EYLGADHAEPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQ
ISEMFDSISYSKGASVIRMLSNFLTEDLFKEGLASYLHAFAYQNTTYLDL
WEHLQKAVDAQTSIRLPDTVRAIMDRWTLQMGFPVITVDTKTGNISQKHF
LLAFDYLWIVPISSIKNGVMQDHYWLRDVSQAQNDLFKTASDDWVLLNVN
VTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNLATAHMVP
VTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLRKQ
VEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTL
FDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEA
DKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIASNVIGQPL
AWDFVQSNWKKLFQDYGSFSFSNLIQGVTRRFSSEFELQQLEQFKKNNMD
VGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5lg6 Chain A Residue 1010 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5lg6 Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H383 H387 E406
Binding residue
(residue number reindexed from 1)		H321 H325 E344
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E350 H383 E384 H387 E406 S464 Y472
Catalytic site (residue number reindexed from 1) E288 H321 E322 H325 E344 S402 Y410
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0001525 angiogenesis
GO:0006508 proteolysis
GO:0030154 cell differentiation
GO:0043171 peptide catabolic process
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5lg6, PDBe:5lg6, PDBj:5lg6
PDBsum5lg6
PubMed28393915
UniProtP15145|AMPN_PIG Aminopeptidase N (Gene Name=ANPEP)

[Back to BioLiP]