Structure of PDB 5l8h Chain A Binding Site BS01

Receptor Information
>5l8h Chain A (length=311) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NEHYFGLVNFGNTCYVNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCL
ADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLN
TIADILQEEKKQELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVD
VEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMIL
ALHLKRFKYMEQLRRYTKLSYRVVFPLELRLFNTSNLDRMYDLVAVVVHC
GSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSE
SGYILFYQSRE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5l8h Chain A Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5l8h A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		C182 C185 C229 C232
Binding residue
(residue number reindexed from 1)		C131 C134 C178 C181
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) N39 C44 H313 D328
Catalytic site (residue number reindexed from 1) N9 C14 H258 D273
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0046872 metal ion binding
GO:0101005 deubiquitinase activity
Biological Process
GO:0001662 behavioral fear response
GO:0006508 proteolysis
GO:0008343 adult feeding behavior
GO:0016579 protein deubiquitination
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0048149 behavioral response to ethanol
GO:0060013 righting reflex
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5l8h, PDBe:5l8h, PDBj:5l8h
PDBsum5l8h
PubMed27650958
UniProtP62068|UBP46_HUMAN Ubiquitin carboxyl-terminal hydrolase 46 (Gene Name=USP46)

[Back to BioLiP]