Structure of PDB 5l2x Chain A Binding Site BS01

Receptor Information
>5l2x Chain A (length=271) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNRKWEAKLKQIEERASPEEPPSIWRLFHRQAQAFNFVKSCKEDVHVFAL
ECKVGDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEF
NKPANPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFS
RHLIFQLHDVAFKDNIHVGNFLRKILQPALDLLPDLSFLVVKNNMGEKHL
FVDLGVYTRNRNFRLYKSSKIGKRVALEVTEDNKFFPIQSKDVSDEYQYF
LSSLVSNVRFSDTLRILTCEP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5l2x Structure and mechanism of human PrimPol, a DNA polymerase with primase activity.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		K10 H46 R47 Q48 D73 G74 Q75 R76 Y78 T285 R286
Binding residue
(residue number reindexed from 1)		K10 H29 R30 Q31 D56 G57 Q58 R59 Y61 T208 R209
Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:5l2x, PDBe:5l2x, PDBj:5l2x
PDBsum5l2x
PubMed27819052
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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