Structure of PDB 5kt3 Chain A Binding Site BS01

Receptor Information
>5kt3 Chain A (length=379) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYGRESRQCPIPSHVIQKLYDVMTPMVD
ILMKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB5kt3 Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
Resolution2.64 Å
Binding residue
(original residue number in PDB)		Q84 K85 Y86 N105 R107 L124 P324 Q325 S326 S328 E329 E330
Binding residue
(residue number reindexed from 1)		Q34 K35 Y36 N55 R57 L74 P274 Q275 S276 S278 E279 E280
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5kt3, PDBe:5kt3, PDBj:5kt3
PDBsum5kt3
PubMed27555320
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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