Structure of PDB 5ksz Chain A Binding Site BS01

Receptor Information
>5ksz Chain A (length=398) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKN
VVRKHISDGVADSGLTLKGFLFLHTLFIQHETTWTVLRRFGYDDDLDLTP
EYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFK
VFPYIPWGPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEYLGYL
GYSILTEQESQASAVTVTRDKKIDLQKKQTQRNVFRCNVIGVKNCGKSGV
LQALLGRNLMRQKKIREDHKSYYAINTVYVYGQEKYLLLHDISESEFLTE
AEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEV
KQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5ksz Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ksz Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		D197 D199 D201 T203 E208
Binding residue
(residue number reindexed from 1)		D16 D18 D20 T22 E27
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:5ksz, PDBe:5ksz, PDBj:5ksz
PDBsum5ksz
PubMed27605430
UniProtQ8IXI2|MIRO1_HUMAN Mitochondrial Rho GTPase 1 (Gene Name=RHOT1)

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